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Understanding the structures of the intermediate species formed in a chemical reaction or process on the way to final products is essential to the successful design of molecules meant to interfere with or influence the outcome of such processes. The challenge in defining a broad-based therapeutic strategy is to identify biochemical processes with common modes and similar intermediates. In this way a general chemistry with broad utility can be developed. The other challenge then lies in tailoring or tuning each potential therapeutic agent to the particular drug application. This is done by systematic modification of the structure of candidates and evaluation of some biochemical, physical, biological or chemical property. The result of these exercises is the development of structural paradigms that can be used in a predictive or correlative sense to guide the discovery process.  

The use of computational techniques to aid these developments is an important facet of the approach. Computation is necessary at 2 levels. Firstly, molecular models of intermediate species and drug candidates aid in the design and can give useful predictions of physical properties. Secondly, the development of a comprehensive database in which biological, physical, chemical, computational and other information is stored for each candidate is critical. This allows empirical quantitative, semi-quantitative and general predictive correlations between structure and activity to be made.

Understanding the shapes and electronic structures of the intermediate species formed in biochemical processes involving carbohydrates, developing such paradigms and charting a synthetic strategy for representative models or analogs of these structures are specific strengths of AFID Therapeutics. The Company has and will continue to develop and refine new structural paradigms for use in the development of its therapeutic candidates.

Afid Therapeutics is pioneering the development of the most extensive platform of new chiral chemical entities meant to emulate key structural, reactive and physicochemical aspects of biomolecules that potentiate and direct the chemistry of life processes. We have introduced new chemical entities that are available as scaffolds or as the cores of new compound libraries that are available for screening purposes. These libraries feature many important ring systems with known or expected biochemical value in potential drugs. The ring systems available in the general screening collections  include piperazines, oxazolines, oxazolidinones, morpholines, pyrrolidines, pyrrolidones, aza-sugars, macrolides, lactones, lactams, thiolactams, cyclopentanes, furans, pyrans, quinolines, isoquinolines, quinolones, purines, pyridines, pyrimidines, imidazoles, benzimidazoles, triazoles plus many more. Other functionalities include sulfonamides, phosphates, phosphonates, sulfates, sulfonates, alcohols, acids, amines, oximes etc. Carbohydrate derivatives, nucleoside analogs, oligosaccharides are included in special library projects. Many of the key molecules used in the preparation of our libraries are available in significant quantities as scaffolds for use in the development of your own libraries. Access to large amounts of key starting chiral compounds can be arranged if you want to make any of these compounds yourself.

How we can work with you

• Our advanced chemical intermediates are available for purchase in quantities ranging from milligrams to tens of kilograms or more.  Call for pricing as our prices are always being adjusted as we scale processes and are able to offer you better pricing.
• Suggest variations and isomers that you would like us to offer or engage us to make a special variation for you.
• Select a collection of scaffolds in smaller amounts from our list of compounds and benefit from special pricing if the total amount of material is above a certain gram threshold. 
• We can prepare a variation of any of our compounds in large quantities specifically to support your drug development activities.
• Engage us to prepare a custom library

 

 

Our screening collections include

piperazines, piperidines, oxazolines, oxazolidinones, morpholines, pyrrolidines, pyrrolidones, aza-sugars, macrolides, lactones, lactams, thiolactams, cyclopentanes, furans, pyrans, quinolines, isoquinolines, quinolones, purines, pyridines, pyrrolidines, pyrrilidones, diazapines, pyrimidines, imidazoles, benzimidazoles, triazoles, sufonamides, phosphates, phosphonates, sulfates, sulfonates, alcohols, acids, amines, peptides, amino acids, sugar derivatives, aziridines and epoxides,